Thermosensitive polymer-modified liposomes that release contents around physiological temperature
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چکیده
منابع مشابه
Thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for triggered release of doxorubicin.
A novel polymer-modified thermosensitive liposome (pTSL) was developed for the delivery of Doxorubicin (DOX) for cancer therapy. Copolymers containing temperature-responsive N-isopropylacrylamide (NIPAAm) and pH-responsive propylacrylic acid (PAA) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, yielding copolymers with dual pH/temperature-dependent p...
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Liposomes are representative lipid nanoparticles widely used for delivering anticancer drugs, DNA fragments, or siRNA to cancer cells. Upon targeting, various internal and external triggers have been used to increase the rate for contents release from the liposomes. Among the internal triggers, decreased pH within the cellular lysosomes has been successfully used to enhance the rate for releasi...
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M. Peller, A. Schwerdt, M. Hossann, H. M. Reinl, R. D. Issels, L. Lindner, and M. Reiser Department of Clinical Radiology, University Hospital of Munich, Munich, Germany, Pharmaceutical Biology-Biotechnology, Department for Pharmacy, University of Munich, Germany, Department of Medicine III, University Hospital of Munich, Germany, Institute for Molecular Immunology, KKG "Hyperthermia"/GSF-Natl....
متن کاملIn vitro stability and content release properties of phosphatidylglyceroglycerol containing thermosensitive liposomes.
Recently, we reported that 1,2-dipalmitoyl-sn-glycero-3-phosphoglyceroglycerol (DPPGOG) prolongs the circulation time of thermosensitive liposomes (TSL). Since the only TSL formulation in clinical trials applies DSPE-PEG2000 and lysophosphatidylcholine (P-lyso-PC), the objective of this study was to compare the influence of these lipids with DPPGOG on in vitro stability and heat-induced drug re...
متن کاملPreparation and Evaluation of Oxaliplatin Thermosensitive Liposomes with Rapid Release and High Stability
Oxaliplatin (OXP) was reported to show low anti-tumor activity when used alone and to display side effects; this low activity was attributed to high partitioning to erythrocytes and low accumulation in tumors. Thermosensitive liposomes (TSL) were considered able to specifically deliver drugs to heated tumors and to resolve the OXP distribution problem. Regretfully, TSL encapsulating doxorubicin...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 1999
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(98)00226-0